A revolutionary new 'dry ink' for laser printers and photocopy machines

ScienceDaily (Nov. 30, 2011) — Imagine someone inventing a "super-toner," a revolutionary new "dry ink" for copiers and laser printers that produces higher-quality, sharper color images more economically, cutting electricity by up to 30 percent. One that also reduces emissions of carbon dioxide -- the main greenhouse gas -- in the production of tens of thousands of tons of toner produced each year. One that reduces the cost of laser printing, making it more affordable in more offices, schools and homes.

Sound like a toner that is too good to be true? Well, a team of scientists at the Xerox Corporation actually invented it. A new episode in the 2011 edition of a  video series from the American Chemical Society (ACS), the world's largest scientific society, focuses on the research and the teamwork that led to this advance.

Titled Prized Science: How the Science Behind ACS Awards Impacts Your Life, the videos are available without charge at the Prized Science website and on DVD.

ACS encourages educators, schools, museums, science centers, news organizations and others to embed links to Prized Science on their websites. The videos discuss scientific research in non-technical language for general audiences. New episodes in the series, which focuses on ACS' 2011 award recipients, will be issued in November and December.

"Science awards shine light on individuals who have made impressive achievements in research," noted ACS President Nancy B. Jackson, Ph.D. "Often, the focus is on the recipients, with the public not fully grasping how the award-winning research improves the everyday lives of people around the world. The Prized Science videos strive to give people with no special scientific knowledge the chance to discover the chemistry behind the American Chemical Society's national awards and see how it improves and transforms our daily lives."

A Revolutionary New "Dry Ink" for Laser Printers & Photocopy Machines features the research of Patricia Burns, Ph.D., Grazyna Kmiecik-Lawrynowicz, Ph.D., Chieh-Min Cheng, Ph.D., and Tie Hwee Ng, Ph.D., winners of the 2011 ACS Award for Team Innovation sponsored by the ACS Corporation Associates. Toner is the fine powder used instead of ink in photocopy machines, laser printers and multifunction devices -- machines that print, copy and fax. The researchers at Xerox developed a new toner called "EA Toner," which stands for "emulsion aggregation." They start with a liquid material that looks like house paint. That's the "emulsion" part. Then, they throw in pigments for color, waxes and other useful things and let everything "aggregate," or stick together. Then, it all dries out, and what's left is a fine powder that they can put into a toner cartridge. That worked fine in the lab, but scaling it up to produce millions of toner cartridges to meet consumers' demands was difficult -- all of the scientists had to work together to make the new toner a commercial reality.

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Gene is first linked to herpes-related cold sores

ScienceDaily (Nov. 30, 2011) — A team of researchers from the University of Utah and the University of Massachusetts has identified the first gene associated with frequent herpes-related cold sores.

The findings were published in the Dec. 1, 2011, issue of the Journal of Infectious Diseases.

Herpes simplex labialis (HSL) is an infection caused by herpes simplex virus type 1 (HSV-1) that affects more than 70 percent of the U.S. population. Once HSV-1 has infected the body, it is never removed by the immune system. Instead, it is transported to nerve cell bodies, where it lies dormant until it is reactivated. The most common visible symptom of HSV-1 reactivation is a cold sore on or around the mouth. Although a majority people are infected by HSV-1, the frequency of cold sore outbreaks is extremely variable and the causes of reactivation are uncertain.

"Researchers believe that three factors contribute to HSV-1 reactivation -- the virus itself, exposure to environmental factors, and genetic susceptibility," says John D. Kriesel, M.D., research associate professor of infectious diseases at the University of Utah School of Medicine and first author on the study. "The goal of our investigation was to define genes linked to cold sore frequency."

Kriesel and his colleagues previously had identified a region of chromosome 21 containing six genes significantly linked to HSL disease using DNA collected from 43 large families to map the human genome. In the current study, Kriesel and his colleagues performed intensive analysis of this chromosome region using single nucleotide polymorphism (SNP) genotyping, a test which identifies differences in genetic make-up between individuals.

"Using SNP genotyping, we were able to identify 45 DNA sequence variations among 618 study participants, 355 of whom were known to be infected with HSV-1," says Kriesel. "We then used two methods called linkage analysis and transmission disequilibrium testing to determine if there was a genetic association between particular DNA sequence variations and the likelihood of having frequent cold sore outbreaks."

Kriesel and his colleagues discovered that an obscure gene called C21orf91 was associated with susceptibility to HSL. They identified five major variations of C21orf91, two of which seemed to protect against HSV-1 reactivation and two of which seemed to increase the likelihood of having frequent cold sore outbreaks.

"There is no cure for HSV-1 and, at this time, there is no way for us to predict or prevent cold sore outbreaks," says Kriesel. "The C21orf91 gene seems to play a role in cold sore susceptibility, and if this data is confirmed among a larger, unrelated population, this discovery could have important implications for the development of drugs that affect cold sore frequency."

Kriesel's University of Utah collaborators include Maurine R. Hobbs, Ph.D., research assistant professor of internal medicine and adjunct assistant professor of human genetics, and Mark F. Leppert, Ph.D., distinguished professor and former chair of human genetics.

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J. D. Kriesel, B. B. Jones, N. Matsunami, M. K. Patel, C. A. St. Pierre, E. A. Kurt-Jones, R. W. Finberg, M. Leppert, M. R. Hobbs. C21orf91 Genotypes Correlate With Herpes Simplex Labialis (Cold Sore) Frequency: Description of a Cold Sore Susceptibility Gene. Journal of Infectious Diseases, 2011; 204 (11): 1654 DOI: 10.1093/infdis/jir633

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Petroleum-eating mushrooms

ScienceDaily (Nov. 30, 2011) — Take a Petri dish containing crude petroleum and it will release a strong odor distinctive of the toxins that make up the fossil fuel. Sprinkle mushroom spores over the Petri dish and let it sit for two weeks in an incubator, and surprise, the petroleum and its smell will disappear. "The mushrooms consumed the petroleum!" says Mohamed Hijri, a professor of biological sciences and researcher at the University of Montreal's Institut de recherche en biologie végétale (IRBV).

Hijri co-directs a project with B. Franz Lang promoting nature as the number one ally in the fight against contamination. Lang holds the Canada Research Chair on Comparative and Evolutionary Genomics and is a professor at the university's Department of Biochemistry. By using bacteria to stimulate the exceptional growth capacity of certain plants and microscopic mushrooms, Hijri and Lang believe they are able to create in situ decontamination units able to successfully attack the most contaminated sites on the planet.

The recipe is simple. In the spring, we plant willow cuttings at 25-centimeter intervals so the roots dive into the ground and soak up the degrading contaminants in the timber along with the bacteria. At the end of the season, we burn the stems and leaves and we are left with a handful of ashes imprisoning all of the heavy metals that accumulated in the plant cells. Highly contaminated soil will be cleansed after just a few cycles. "In addition, it's beautiful," says Hijri pointing to a picture of dense vegetation covering the ground of an old refinery after just three weeks.

Thanks to the collaboration of an oil company from the Montreal area, the researchers had access to a microbiological paradise: an area where practically nothing can grow and where no one ventures without protective gear worthy of a space traveler. This is where Hijri collected microorganisms specialized in the ingestion of fossil fuels. "If we leave nature to itself, even the most contaminated sites will find some sort of balance thanks to the colonization by bacteria and mushrooms. But by isolating the most efficient species in this biological battle, we can gain a lot of time."

Natural and artificial selection

This is the visible part of the project, which could lead to a breakthrough in soil decontamination. The project is called Improving Bioremediation of Polluted Soils Through Environmental Genomics and it requires time-consuming sampling and fieldwork as well as DNA sequencing of the species in question. The project involves 16 researchers from the University of Montreal and McGill University, many of which are affiliated with the IRBV. The team also includes four researchers, lawyers and political scientists, specializing in the ethical, environmental, economic, legal and social aspects of genomics.

The principle is based on a well-known process in the sector called phytoremediation that consists in using plant matter for decontamination. "However, in contaminated soils, it isn't the plant doing most of the work," says Lang. "It's the microorganisms i.e. the mushrooms and bacteria accompanying the root. There are thousands of species of microorganisms and our job is to find the best plant-mushroom-bacteria combinations."

Botanist Michel Labrecque is overseeing the plant portion of the project. The willow seems to be one of the leading species at this point given its rapid growth and premature foliation. In addition, its stem grows even stronger once it has been cut. Therefore, there is no need to plant new trees every year. However, the best willow species still needs to be determined.

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Engineered botulism toxins could have broader role in medicine

ScienceDaily (Nov. 30, 2011) — The most poisonous substance on Earth -- already used medically in small doses to treat certain nerve disorders and facial wrinkles -- could be re-engineered for an expanded role in helping millions of people with rheumatoid arthritis, asthma, psoriasis and other diseases, scientists are reporting. Their study appears in ACS' journal Biochemistry.

Edwin Chapman and colleagues explain that toxins, or poisons, produced by Clostridium botulinum bacteria, cause of a rare but severe form of food poisoning, are the most powerful toxins known to science. Doctors can inject small doses, however, to block the release of the neurotransmitters, or chemical messengers, that transmit signals from one nerve cell to another. The toxins break down a protein in nerve cells that mediates the release of neurotransmitters, disrupting nerve signals that cause pain, muscle spasms and other symptoms in certain diseases. That protein exists not just in nerve cells, but in other cells in the human body. However, these non-nerve cells lack the receptors needed for the botulinum toxins to enter and work. Chapman's group sought to expand the potential use of the botulinum toxins by hooking it to a molecule that can attach to receptors on other cells.

Their laboratory experiments showed that these engineered botulinum toxins do work in non-nerve cells, blocking the release of a protein from immune cells linked to inflammation, which is the underlying driving force behind a range of diseases. Such botulinum toxin therapy holds potential in a range of chronic inflammatory diseases and perhaps other conditions, which could expand the role of these materials in medicine.

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Felix L. Yeh, Yiming Zhu, William H. Tepp, Eric A. Johnson, Paul J. Bertics, Edwin R. Chapman. Retargeted Clostridial Neurotoxins as Novel Agents for Treating Chronic Diseases. Biochemistry, 2011; 50 (48): 10419 DOI: 10.1021/bi201490t

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Two out of three medical students do not know when to wash their hands

ScienceDaily (Dec. 1, 2011) — Only 21 percent of surveyed medical students could identify five true and two false indications of when and when not to wash their hands in the clinical setting, according to a study published in the December issue of the American Journal of Infection Control, the official publication of APIC -- the Association for Professionals in Infection Control and Epidemiology.

Three researchers from the Institute for Medical Microbiology and Hospital Epidemiology at Hannover Medical School in Hannover, Germany collected surveys from 85 medical students in their third year of study during a lecture class that all students must pass before bedside training and contact with patients commences. Students were given seven scenarios, of which five ("before contact to a patient," "before preparation of intravenous fluids," "after removal of gloves," "after contact to the patient's bed," and "after contact to vomit") were correct hand hygiene (HH) indications. Only 33 percent of the students correctly identified all five true indications, and only 21 percent correctly identified all true and false indications.

Additionally, the students expected that their own HH compliance would be "good" while that of nurses would be lower, despite other published data that show a significantly higher rate of HH compliance among nursing students than among medical students. The surveyed students further believed that HH compliance rates would be inversely proportional to the level of training and career attainment of the physician, which confirms a previously discovered bias among medical students that is of particular concern, as these higher-level physicians are often the ones training the medical students at the bedside.

"There is no doubt that we need to improve the overall attitude toward the use of alcohol-based hand rub in hospitals," conclude the authors. "To achieve this goal, the adequate behavior of so-called 'role models' is of particular importance."

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K. Graf and I.F. Chaberny, R.-P. Vonberg. Beliefs about hand hygiene: A survey in medical students in their first clinical year. American Journal of Infection Control, Volume 39, Issue 10 (December 2011)

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World's first captive breeding of Ozark hellbenders

ScienceDaily (Dec. 1, 2011) — Ozark hellbenders have been bred in captivity -- a first for either of the two subspecies of hellbender. The decade-long collaboration of the Saint Louis Zoo's Ron Goellner Center for Hellbender Conservation and the Missouri Department of Conservation has yielded 63 baby hellbenders.

The first hellbender hatched on Nov. 15, and currently there are approximately 120 additional eggs that should hatch within the next week. The eggs are maintained in climate- and water quality-controlled trays behind the scenes in the Zoo's Herpetarium. For 45 to 60 days after emerging, the tiny larvae will retain their yolk sack for nutrients and move very little as they continue their development. As the larvae continue to grow, they will develop legs and eventually lose their external gills by the time they reach 1.5 to 2 years of age. At sexual maturity, at 5 to 8 years of age, adult lengths can approach two feet. Both parents are wild bred: the male has been at the Zoo for the past two years and the female arrived this past September.

Rivers in south-central Missouri and adjacent Arkansas once supported up to 8,000 Ozark hellbenders. Today, fewer than 600 exist in the world-so few that the amphibian was added in October 2011 to the federal endangered species list.

Due to these drastic declines, captive propagation became a priority in the long-term recovery of the species. Once the captive-bred larvae are 3 to 8 years old, they can then be released into their natural habitat-the Ozark aquatic ecosystem.

Also known by the colloquial names of "snot otter" and "old lasagna sides," the adult hellbender is one of the largest species of salamanders in North America, with its closest relatives being the giant salamanders of China and Japan, which can reach five feet in length.

With skin that is brown with black splotches, the Ozark hellbender has a slippery, flattened body that moves easily through water and can squeeze under rocks on the bottom of streams.

Like a Canary in a Coal Mine

Requiring cool, clean running water, the Ozark hellbender is also an important barometer of the overall health of that ecosystem-an aquatic "canary in a coal mine."

"Capillaries near the surface of the hellbender's skin absorb oxygen directly from the water -- as well as hormones, heavy metals and pesticides," said Jeff Ettling, Saint Louis Zoo curator of herpetology and aquatics. "If there is something in the water that is causing the hellbender population to decline, it can also be affecting the citizens who call the area home."

"We have a 15- to 20-year window to reverse this decline," added Missouri Department of Conservation Herpetologist Jeff Briggler, who cites a number of reasons for that decline from loss of habitat to pollution to disease to illegal capture and overseas sale of the hellbender for pets. "We don't want the animal disappearing on our watch."

Reversing A Decline

In 2001, the Ozark Hellbender Working Group of scientists from government agencies, public universities and zoos in Missouri and Arkansas launched a number of projects to staunch that decline. These included egg searches, disease sampling and behavioral studies.

In 2004, funding from private donors, the Missouri Department of Conservation, the United States Fish & Wildlife Services and the Zoo covered the cost of building sophisticated facilities including climate-controlled streams to breed the hellbender.

The hellbender propagation facilities include two outdoor streams that are 40 feet long and six feet deep. The area is landscaped with natural gravel, large rocks for hiding and artificial nest boxes, where the fertilized eggs were discovered. A nearby building houses state-of-the-art life support equipment used to filter the water and maintain the streams at the proper temperature.

In addition, two large climate-controlled rooms in the basement of the Zoo's Charles H. Hoessle Herpetarium are the headquarters for the program. The facilities recreate hellbender habitat with closely monitored temperatures, pumps to move purified water, sprinklers synced to mimic the exact precipitation and lights that flick on or dim to account for brightness and shade. The largest room includes a 32-foot simulated stream, complete with native gravel and large rocks for hiding. It houses a breeding group of adult Ozark hellbenders from the North Fork of the White River in Missouri; offspring from these hellbenders will eventually be released back into the wild.

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Texas drought visible in new national groundwater maps

ScienceDaily (Nov. 30, 2011) — The record-breaking drought in Texas that has fueled wildfires, decimated crops and forced cattle sales has also reduced levels of groundwater in much of the state to the lowest levels seen in more than 60 years, according to new national maps produced by NASA and distributed by the National Drought Mitigation Center at the University of Nebraska-Lincoln.

The latest groundwater map, released on Nov. 29, shows large patches of maroon over eastern Texas, indicating severely depressed groundwater levels. The maps, generated weekly by NASA's Goddard Space Flight Center in Greenbelt, Md., are publicly available on the Drought Center's website.

"Texas groundwater will take months or longer to recharge," said Matt Rodell, a hydrologist based at Goddard. "Even if we have a major rainfall event, most of the water runs off. It takes a longer period of sustained greater-than-average precipitation to recharge aquifers significantly."

The maps are based on data from NASA's Gravity Recovery and Climate Experiment (GRACE) satellites, which detect small changes in Earth's gravity field caused primarily by the redistribution of water on and beneath the land surface. The paired satellites travel about 137 miles (220 km) apart and record small changes in the distance separating them as they encounter variations in Earth's gravitational field.

To make the maps, scientists used a sophisticated computer model that combines measurements of water storage from GRACE with a long-term meteorological dataset to generate a continuous record of soil moisture and groundwater that stretches back to 1948. GRACE data goes back to 2002. The meteorological data include precipitation, temperature, solar radiation and other ground- and space-based measurements.

The color-coded maps show how much water is stored now as a probability of occurrence in the 63-year record. The maroon shading over eastern Texas, for example, shows that the level of dryness over the last week occurred less than two percent of the time between 1948 and the present.

The groundwater maps aren't the only maps based on GRACE data that the Drought Center publishes each week. The Drought Center also distributes soil moisture maps that show moisture changes in the root zone down to about 3 feet (1 meter) below the surface, as well as surface soil moisture maps that show changes within the top inch (2 cm) of the land.

"All of these maps offer policymakers new information into subsurface water fluctuations at regional to national scales that has not been available in the past," said the Drought Center's Brian Wardlow. The maps provide finer resolution or are more consistently available than other similar sources of information, and having the maps for the three different levels should help decision makers distinguish between short-term and long-term droughts.

"These maps would be impossible to generate using only ground-based observations," said Rodell. "There are groundwater wells all around the United States and the U.S. Geological Survey does keep records from some of those wells, but it's not spatially continuous and there are some big gaps."

The maps also offer farmers, ranchers, water resource managers and even individual homeowners a new tool to monitor the health of critical groundwater resources. "People rely on groundwater for irrigation, for domestic water supply, and for industrial uses, but there's little information available on regional to national scales on groundwater storage variability and how that has responded to a drought," Rodell said. "Over a long-term dry period there will be an effect on groundwater storage and groundwater levels. It's going to drop quite a bit, people's wells could dry out, and it takes time to recover."

The maps are the result of a NASA-funded project at the Drought Center and NASA Goddard to make it easier for the weekly U.S. Drought Monitor to incorporate data from the GRACE satellites. NASA's Jet Propulsion Laboratory, Pasadena, Calif., developed GRACE and manages the mission for NASA. The groundwater and soil moisture maps are updated each Tuesday.

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