Is it Alzheimer's disease or another dementia? Marker may give more accurate diagnosis

ScienceDaily (Nov. 30, 2011) — New research finds a marker used to detect plaque in the brain may help doctors make a more accurate diagnosis between two common types of dementia -- Alzheimer's disease and frontotemporal lobar degeneration (FTLD). The study is published in the November 30, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology."These two types of dementia share similar symptoms, so telling the two apart while a person is living is a real challenge,...

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Yeast model connects Alzheimer's disease risk and amyloid beta toxicity

ScienceDaily (Oct. 27, 2011) — In a development that sheds new light on the pathology of Alzheimer's disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the effects of a peptide toxic to nerve cells in the brains of AD patients.The scientists, working in and in collaboration with the lab of Whitehead Member Susan Lindquist, established these previously unknown links in an unexpected way. They used a very simple cell...

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Strides made toward drug therapy for inherited kidney disease

ScienceDaily (Oct. 27, 2011) — Scientists at UC Santa Barbara have discovered that patients with an inherited kidney disease may be helped by a drug that is currently available for other uses. The findings are published in this week's issue of the Proceedings of the National Academy of Sciences.Over 600,000 people in the U.S., and 12 million worldwide, are affected by the inherited kidney disease known as autosomal-dominant polycystic kidney disease (ADPKD). The disease is characterized by the...

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Step toward unraveling Alzheimer's disease

ScienceDaily (Oct. 27, 2011) — Scientists outline new methods for better understanding links between specific proteins and the risks associated with Alzheimer's disease in an article co-authored by University of Alabama researchers and publishing in Science Express.In experiments using a series of model organisms, including yeast, microscopic roundworms and rats, the researchers show how basic mechanisms inside cells are disrupted when a specific human protein, known as the amyloid beta peptide,...

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To diagnose heart disease, visualization experts recommend a simpler approach

ScienceDaily (Oct. 27, 2011) — A team of computer scientists, physicists, and physicians at Harvard has developed a simple yet powerful method of visualizing human arteries that may result in more accurate diagnoses of atherosclerosis and heart disease.The prototype tool, called "HemoVis," creates a 2D diagram of arteries that performs better than the traditional 3D, rainbow-colored model. In a clinical setting, the tool has been shown to increase diagnostic accuracy from 39% to 91%.Presented Oct....

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Body’s molecular sensors may trigger autoimmune disease

ScienceDaily (Oct. 27, 2011) — Bruce Beutler, MD, a co-recipient of the 2011 Nobel Prize in Medicine, has coauthored an article describing a novel molecular mechanism that can cause the body to attack itself and trigger an autoimmune disease. The article is published online ahead of print in the Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc.In the article, entitled "Intracellular Nucleic Acid Sensors and Autoimmunity," Argyrios Theofilopoulos,...

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Healthy mouth bacteria provide ideal conditions for gum disease

ScienceDaily (Oct. 27, 2011) — Normal bacteria which live in our mouths provide the catalyst for the development of gum disease, a debilitating condition which leads to painful gums and the loosening of teeth, new research from Queen Mary, University of London has found.The unexpected finding could pave the way for the development of preventative measures in tackling gum, or periodontal disease*, by manipulating the normal bacteria in the same way that probiotic yoghurt works to protect the intestine.Researchers...

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