Joking, pretending with toddlers gives them head start in life skills

ScienceDaily (Oct. 27, 2011) — Parents who joke and pretend with their toddlers are giving their children a head start in terms of life skills. Most parents are naturals at playing the fool with their kids, says a new research project funded by the Economic and Social Research Council (ESRC). However parents who feel they may need a little help in doing this can learn to develop these life skills with their tots.

"Parents, carers and early years educators shouldn't underestimate the importance of interacting with young children through jokes and pretending," researcher Dr Elena Hoicka points out. "Spending time doing this fun stuff with kids helps them learn how to do it themselves and gives them a set of skills which are important in childhood and beyond."

The latest research findings on joking and pretending with children will be highlighted at a half-day event organised as part of the ESRC's Festival of Social Science 2011. One key aim of the event will be to boost parents' confidence in joking and pretending with their toddlers through a range of hands-on activities.

Dr Hoicka's study has examined how the two very similar concepts of joking and pretending develop in children aged between 15 and 24 months. Explaining the difference between joking and pretending, Dr Hoicka says: "Both involve intentionally doing or saying the wrong thing. However, joking is about doing something wrong just for the sake of it. In contrast, pretending is about doing something wrong which is imagined to be right. For example, parents might use a sponge like a duck while pretending but use a cat as a duck when joking."

The study examined whether parents offer different cues such as tone or pitch of voice in order to help their toddlers understand and differentiate between joking and pretending. Findings reveal that parents rely on a range of language styles, sound and non-verbal cues. For example, when pretending, parents often talk slowly and loudly and repeat their actions. Conversely, parents tend to cue their children to jokes by showing their disbelief through language, and using a more excited tone of voice.

"We found that most parents employ these different cues quite naturally to help their toddlers understand and differentiate these concepts," Dr Hoicka points out. "While not all parents feel confident in their natural abilities, the research does show that making the effort to interact in this way with toddlers is important. Knowing how to joke is great for making friends, dealing with stress, thinking creatively and learning to 'think outside the box'. Pretending helps children learn about the world, interact with others, be creative and solve problems."

Parents can learn more about the different cues used in joking and pretending during an event to be held later this week. "We will be offering a range of activities to help parents experiment with joking and pretending," says Dr Hoicka. "We will also give some short talks on the early development of joking and pretending in toddlers as well as some initial findings from our research project."

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Gender differences: Viewing TV coverage of terrorism has more negative effect on women, study finds

ScienceDaily (Oct. 27, 2011) — Exposure to television coverage of terrorism causes women to lose psychological resources much more than men, which leads to negative feelings and moodiness. This has been shown in a new study, conducted at the University of Haifa and soon to be published in Anxiety, Stress & Coping, that examined the differences between men and women in a controlled experiment environment.

An earlier study conducted by Prof. Moshe Zeidner of the Department of Counseling and Human Development at the University of Haifa and Prof. Hasida Ben-Zur of the University of Haifa's School of Social Work, has shown that viewing television coverage of terrorism causes viewers to lose psychological resources, such the sense of significance or success, and causes a feeling of being threatened. The current study set out to examine whether there are differences between men and women in the levels of psychological resource loss.

According to the authors of the new study, earlier research dealing with gender differences in the effects of traumatic events examined data based on questionnaires relating to past experiences. The present study is now taking a new step as it is examining these differences in a controlled experiment environment in which all of the participants are exposed to the same events and report on their feelings immediately following the events.

In order to create such a controlled environment, men and women were shown news video clips reporting on terrorist attacks that took place over the past few years and which resulted in serious casualties. In parallel, two other groups of men and women were shown news coverage of "regular," everyday news events.

The results of this study show that the women who viewed terrorism coverage testified to higher levels of feeling threatened and lower levels of psychological resources compared to the men who viewed the same news reports. These gender differences were not found amongst the control groups. The study has also found that the feeling of being threatened and loss of resources has an effect on the senses and lead to a higher level of negativity, such as hostility and moodiness.

"It is possible that the differences between men and women are founded in gender socialization, 'teaching' women to respond to terrorism with more anxiety than men," said Prof. Moshe Zeidner.

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Hasida Ben-Zur, Moshe Zeidner. Gender differences in loss of psychological resources following experimentally-induced vicarious stress. Anxiety, Stress & Coping, 2011; DOI: 10.1080/10615806.2011.619526

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Speedy 3-D X-rays in the operating room

ScienceDaily (Oct. 27, 2011) — Having an operation always places strain on patients, and this is especially true of complicated operations. Surgeons use 3D X-rays to check the results before the patient has left the operating room. This does help to avoid possible complications, but it also means interrupting the surgery. Fraunhofer researchers are now developing a 3D X-ray system that can be integrated seamlessly into operating procedure -- with no more forced interruptions.

To find out how this system works, visit the Medica 2011 trade fair in Düsseldorf from November 16 to 19.

Mrs. S. is more than a little anxious: she is due to be given a spinal implant in three days' time. The elderly lady is worried about complications -- and not without reason, since complicated operational procedures such as those on the spine, the head or the ankle are a challenge even for highly experienced surgeons. In order to reduce the risk of complications in more difficult operations and to avoid the need for follow-up surgery, doctors carry out progress checks with the help of three-dimensional X-ray images while the operation is in progress. These 3D images allow them to check on the position of implants and fracture fragments, so as to determine the relative positions of pieces of bone or to position implants with millimeter accuracy. The trouble is, currently available 3D X-ray systems such as C-arms interfere with the surgeon's work. The X-ray source and detector have to move in circles around the patient, which takes up a lot of space; if the C-arm were installed on the operating table permanently, it would impede access to patients. So the device must be wheeled over to the operating table to capture the images and then moved out of the way again. This is a nuisance -- and it takes up time, as it entails an interruption to the surgery.

Researchers at the Fraunhofer Institute for Production Systems and Design Technology IPK are currently working on a solution to this problem. Together with the Charité -- Universitätsmedizin Berlin university hospital and Ziehm Imaging GmbH, they are developing ORBIT, a 3D X-ray scanner that can be integrated into operations and does not cause any delays.

"Unlike existing three-dimensional imaging procedures, ORBIT doesn't have to surround the patient to capture images. Instead, it's an open system in which the X-ray source follows a circular path above the operating table. This makes capturing images much quicker, because it does away with time-consuming preparations," says Professor Dr.-Ing. Erwin Keeve of the Berliner Zentrum für Mechatronische Medizintechnik, a center founded by the IPK and Charité. "It takes about 15 minutes to bring a C-arm into position, record individual projected images of the patient and then convert them into 3D image data. Since X-ray scanning takes less time with ORBIT, it speeds up the overall surgical procedure. Plus it's an easier system to use, which means doctors will be more inclined to make this diagnostic tool a routine part of their work," Keeve explains. The device has another big advantage: While implants and screws can cause interference in C-arm scans, ORBIT images feature far fewer artifacts caused by these metal objects because its X-ray source and its detector do not move in the same plane. Keeve is happy to report that "our initial experiments have been a success."

Modular system

ORBIT is made up of three modules: There is a maneuverable X-ray source fitted to an articulated bracket. This swivel arm can be attached to the ceiling or mounted on a wheeled stand for mobile applications, but either way the X-ray scans are always carried out from above. There is a digital flat panel detector recessed into the operating table. Finally, there is a monitor -- either mobile or wall-mounted -- to display the X-ray images. The researchers have already filed a patent application for this system.

Construction of an initial prototype is currently underway and comprehensive testing will begin in 2012. The system is set to be ready for market in three to five years' time. Those who wish to find out more about ORBIT will have their first chance at Medica 2011 in Düsseldorf.

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Lung stem cells offer therapeutic clues

ScienceDaily (Oct. 27, 2011) — Guided by insights into how mice recover after H1N1 flu, researchers at Harvard Medical School and Brigham and Women's Hospital, together with researchers at A*STAR of Singapore, have cloned three distinct stem cells from the human airways and demonstrated that one of these cells can form into the lung's alveoli air sac tissue. What's more, the researchers showed that these same lung stem cells are rapidly deployed in a dynamic process of lung regeneration to combat damage from infection or chronic disease.

"These findings suggest new cell- and factor-based strategies for enhancing lung regeneration following acute damage from infection, and even in chronic conditions such as pulmonary fibrosis," said Frank McKeon, professor of cell biology at Harvard Medical School. Other senior authors on the paper include Wa Xian of the Institute of Medical Biology in Singapore and Brigham and Women's Hospital, and Christopher Crum, Director of Women's and Perinatal Pathology at Brigham and Women's Hospital. The researchers worked as part of an international consortium involving scientists from Singapore and France.

The findings will be reported in the Oct. 28 issue of Cell.

For many years, clinicians have observed that patients who survive acute respiratory distress syndrome (ARDS), a form of airway damage involving wholesale destruction of large regions of lung tissue, often recover considerable pulmonary function within six to 12 months. But researchers did not know whether that recovery was due to lung regeneration or to some other kind of adaptive remodeling.

"This study helps clear up the uncertainty," said McKeon. "We have found that the lungs do in fact have a robust potential for regeneration, and we've identified the specific stem cells responsible."

To probe the potential for lung regeneration, Xian, McKeon and colleagues infected mice with a sublethal dosage of a virulent strain of H1N1 influenza A virus. After two weeks of infection, these mice showed a loss of nearly 60 percent of tissue in the lung air sacs after two weeks of infection, but -- remarkably -- by three months, the lungs appeared completely normal by all histological criteria.

These findings demonstrated true lung regeneration, but raised the question of the nature of the stem cells underlying this regenerative process.

Adapting the methods for cloning epidermal skin stem cells pioneered by Howard Green, the George Higginson Professor of Cell Biology at HMS and the 2010 Warren Alpert Foundation Prize recipient, the researchers cloned stem cells from the lung airway in a dish and watched as they differentiated to unusual structures with gene profiles similar to alveoli, the cells in the lung's air sacs.

"This was startling to us," Xian said, "and even more so as we observed the same stem cell populations involved in alveoli formation during the peak of H1N1 infections in mice." The researchers genetically traced the formation of new alveoli to a discrete population of stem cells in the fine endings of the conducting airways that rapidly divide in response to infection and migrate to sites of lung damage.

The scientists were intrigued when molecular dissection of these incipient alveoli revealed the presence of an array of signaling molecules known to control cell behavior, suggesting the possibility that these molecules coordinate the regeneration process itself.

Currently the team is testing the possibility that the secreted factors they observed might promote regeneration, suggesting a therapeutic approach for conditions such as chronic obstructive pulmonary disease and even asthma. They also foresee the possibility that these distal airway stem cells could contribute to repairing lungs scarred by irreversible fibrosis, conditions resistant to present therapies.

This work was supported by the National Heart, Lung, and Blood Institute, the Institute of General Medical Sciences, the National Cancer Institute, and the Defense Advanced Research Projects Agency.

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Pooja A. Kumar, Yuanyu Hu, Yusuke Yamamoto, Neo Boon Hoe, Tay Seok Wei, Dakai Mu, Yan Sun, Lim Siew Joo, Rania Dagher, Elisabeth M. Zielonka, De Yun Wang, Bing Lim, Vincent T. Chow, Christopher P. Crum, Wa Xian, Frank McKeon. Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection. Cell, 28 October 2011 DOI: 10.1016/j.cell.2011.10.001

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Body’s molecular sensors may trigger autoimmune disease

ScienceDaily (Oct. 27, 2011) — Bruce Beutler, MD, a co-recipient of the 2011 Nobel Prize in Medicine, has coauthored an article describing a novel molecular mechanism that can cause the body to attack itself and trigger an autoimmune disease. The article is published online ahead of print in the Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc.

In the article, entitled "Intracellular Nucleic Acid Sensors and Autoimmunity," Argyrios Theofilopoulos, Dwight Kono, Bruce Beutler, and Roberto Baccala, The Scripps Research Institute (La Jolla, California), review the scientific evidence that supports the role of molecular sensors located inside cells in the initiation not only of protective and inflammatory immune responses, but also in an autoimmune response. These sensors recognize nucleic acid signatures that may be shared by foreign pathogens and the body's own DNA and RNA.

Dr. Beutler is one of three recipients awarded the Nobel Prize in Physiology and Medicine. He shares half of the prize with Jules Hoffman, PhD for their discoveries related to how the body's immune system fights disease through the activation of an innate immune response. The third recipient, Ralph Steinman, MD, who died before the Nobel Prizes were announced, previously published an article in AIDS Research and Human Retroviruses. Mary Ann Liebert, Inc. congratulates the three winners for the work and contributions to medicine for which they are being recognized.

The Journal of Interferon & Cytokine Research, led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, and Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the Official Journal of the International Society for Interferon and Cytokine Research. Tables of content and a free sample issue may be viewed online at www.liebertpub.com/jir

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Argyrios N. Theofilopoulos, Dwight H. Kono, Bruce Beutler, Roberto Baccala. Intracellular Nucleic Acid Sensors and Autoimmunity. Journal of Interferon & Cytokine Research, 2011; 111027061355005 DOI: 10.1089/jir.2011.0092Ralf Ignatius, Yang Wei, Sylvie Beaulieu, Agegnehu Gettie, Ralph M. Steinman, Melissa Pope, Svetlana Mojsov. Short Communication: The Immunodeficiency Virus Coreceptor, Bonzo/STRL33/TYMSTR, Is Expressed by Macaque and Human Skin- and Blood-Derived Dendritic Cells. AIDS Research and Human Retroviruses, 2000; 16 (11): 1055 DOI: 10.1089/08892220050075318

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What role do cytokines play in autoimmune diseases?

ScienceDaily (Oct. 27, 2011) — Cytokines, a varied group of signaling chemicals in the body, have been described as the software that runs the immune system, but when that software malfunctions, dysregulation of the immune system can result in debilitating autoimmune diseases such as lupus, arthritis, and diabetes. Leading experts in the field of cytokine research present their most up-to-date findings and unique perspectives on the role of cytokines in autoimmune diseases in a special issue of the Journal of Interferon & Cytokine Research, a peer-reviewed publication of Mary Ann Liebert, Inc.

Dhan Kalvakolanu, PhD, University of Maryland School of Medicine, Journal Co-Editors-in-Chief Ganes C. Sen, PhD, and Thomas A. Hamilton, PhD, Cleveland Clinic Foundation, together with Guest Editors Kamal Moudgil, MD, PhD, University of Maryland School of Medicine, and Divaker Choubey, PhD, University of Cincinnati have compiled a wealth of in-depth review articles, original research, and insightful perspectives from expert researchers on the evolving understanding of how cytokines can both contribute to the initiation of autoimmune diseases and control the inflammation associated with the acute phase of these diseases. This special issue of the Journal is the first in a two-volume collection of articles.

In his introductory Editorial, Dr. Kalvakolanu identifies cytokines as the first step in the onset of immune responses in which the body attacks its own cells and tissues, leading to the development of autoimmune diseases. Drs. Moudgil and Choubey present an overview of the role cytokines play in the induction, regulation, and treatment of autoimmunity. An original research article, "Critical Cytokine Pathways to Cardiac Inflammation," by Noel Rose, PhD, The Johns Hopkins Schools of Medicine and Public Health (Baltimore, MD), describes a mouse model of autoimmune myocarditis -- inflammation of the heart muscles -- that is triggered by infection with Coxsackievirus B3. The model allows researchers to study the cytokine pathways involved in this disease, with the goal of identifying chemical markers that could be used to predict patients more likely to experience an autoimmune reaction after infection.

The Journal of Interferon & Cytokine Research is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the Official Journal of the International Society for Interferon and Cytokine Research. Tables of content and a free sample issue may be viewed online at www.liebertpub.com/jir

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Belief in god cuts two ways, study finds

ScienceDaily (Oct. 27, 2011) — Being reminded of the concept of God can decrease people's motivation to pursue personal goals but can help them resist temptation, according to new research published by the American Psychological Association.

"More than 90 percent of people in the world agree that God or a similar spiritual power exists or may exist," said the study's lead author, Kristin Laurin, PhD, of the University of Waterloo in Canada. "This is the first empirical evidence that simple reminders of God can diminish some types of self-regulation, such as pursuing one's goals, yet can improve others, such as resisting temptation."

A total of 353 college students, with an average age 19 and 186 of whom were women, participated in six experiments to determine how the idea of God can indirectly influence people's motivations, even among those who said they were not religious. The students did not have to have an opinion on the existence of a god or any other spiritual power. The findings were reported in the online version of the Journal of Personality and Social Psychology®.

In one experiment, engineering students completed a "warm-up" word task. They were asked to form grammatically correct sentences using four words from sets of five. Some students were provided either God or God-related words (divine, sacred, spirit and prophet), while the control group used more neutral words (ball, desk, sky, track and box). Next, each student had to form as many words as they could in five minutes, using any combination of specific letters. The researchers determined the students' motivation level by the number of words they produced. The more motivated they were, the more words they produced. They were told that a good performance could help predict if they would succeed in an engineering career.

Several weeks before this experiment, the students had been asked if they believed outside factors (other people, beings, forces beyond their control) had an influence on their careers. Among participants who said outside factors such as God might influence their career success, those who did the God-related word task performed worse than those who used neutral words. There was no difference in performance among the participants who did not believe outside factors influenced their career success.

Researchers also measured the importance participants placed on a number of values, including achievement. Participants reminded of God placed the same value on achievement as did participants primed with the more neutral words. "This suggests that our findings did not emerge because the participants reminded of God devalued achievement," said Laurin.

A second set of experiments looked at participants' ability to resist temptation after being reminded about God. In one study, participants who said eating healthy food was important to them ate fewer cookies after reading a short passage about God than those who read a passage unrelated to God.

Participants who read a short God-related passage reported greater willingness to resist temptations to achieve a major goal, such as maintaining a healthy weight, finding a long-term relationship or having a successful career. This effect was found only among participants who had previously said they believe an omniscient entity watches over them and notices when they misbehave.

The level of participants' religious devotion had no impact on the outcomes in any of the experiments, according to the researchers.

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Kristin Laurin, Aaron C. Kay, Gráinne M. Fitzsimons. Divergent effects of activating thoughts of god on self-regulation. Journal of Personality and Social Psychology, 2011; DOI: 10.1037/a0025971

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